Hair Regrowth Serum
Pure Guild Hair Regrowth Serum, Shampoo, and Conditioner set the new benchmark for molecular purity in topical treatments:
- Pure Guild extracts pristine active compounds mechanically, using no industrial solvents or damaging heat, creating a standard of purity by which other products can be measured.
- Pure Guild employs only the active ingredients proven most effective in rigorous clinical trials, creating a standard of cosmeceutical performance.
Pristine Mechanical Extraction
Active ingredients in Pure Guild Hair Regrowth Serum, Shampoo, and Conditioner maintain their molecular integrity and full spectrum of biological activities because no solvents are used and no heat is applied to extract them.
Pure Guild employs only gentle mechanical compression over time to render highly effective compounds from potent raw materials. Although costly, this process yields a superior molecule, while other organic brands use chemical solvents like hexane or ether, which adulterate the final product, and heat distillation, which inhibits therapeutic properties.
Super-premium Pure Guild cosmeceuticals contain no sodium lauryl sulfate or other detergents. They are strictly hypoallergenic, non-irritating, and never tested on animals.
Latest BioTechnical Science In Hair
Pure Guild Hair Regrowth Serum, Shampoo, and Conditioner incorporate only the active ingredients proven most effective via clinical trials. Dramatically, one extract of the botanical Lupinus albus, native to the Mediterranean region, has shown in multiple scientific studies to control testosterone and boost the density, activity, and blood supply of delicate hair follicles:
- After 86 days of clinical treatment, Lupinus albus extract increased the density of hair by 12 percent, the number of follicles in anagen growth phase by 17 percent, and the ratio of active to dormant follicles by an astonishing 118 percent.
- L albus extract inhibited the enzyme 5α-reductase by 18 to 31 percent — more than the oral drug finasteride — and reduced formation of the dihydrotestosterone that would cause hair follicles to miniaturize and eventually to stop producing hair.
- L albus stimulated vascular endothelial growth factor by 17 to 30 percent and stimulated the development of new vascular branching to deliver essential nutrients to growing hair.
STATE OF THE SCIENCE
Hair is a social marker, an important component of attraction, and the loss of hair is associated with a loss of power. Male pattern balding starts at an early age, between 15 and 20, and may progress to total baldness very rapidly. To arrest and delay significant loss, specialists recommend prevention at the first sight of symptoms.
The leader in cosmeceutical science, Pure Guild researches hair pathology in depth and offers the most effective topical treatments to combat balding. Currently, attention is focused on active ingredients that affect four factors of the hair cycle: epithelial cells, peripheral nervous system, immune system, and vascular system. Pure Guild has developed today’s state-of-the-science treatment for hair regrowth, Lupinus albus extract, derived from the white lupine native to the Mediterranean. Rich in peptides, trace elements, and vitamins, the extract has been proven in clinical trials.
Lupinus albus extract performs simultaneously on three fronts of the hair cycle:
- Enzymatic: L albus restores hormonal balance by inhibiting activity of the enzyme 5α-reductase II.
- Metabolic: L albus stimulates metabolic activity in hair-follicle cells, favoring keratinization and hair growth.
- Vascular: L albus improves vascularization of the follicle, facilitating nutrient supply to construct new hair.
Tested in vivo, the active botanical extract deployed in Pure Guild Hair Regrowth Serum, Shampoo, and Conditioner is proven to favor hair growth and return hair density to normal levels. In each hair cycle, a follicle undergoes three phases: anagen, catagen, and telogen.
The active phase of hair growth lasts for three to five years. Normally, 80–85 percent of follicles are in anagen phase. Each can yield about 20 terminal hairs. Divided into six stages, anagen requires intense metabolic activity in the hair bulb:
Stage I: The follicle is regenerated from a bulge — believed to be stem cells — located where the sebaceous gland opens onto the shaft.
Stage II: Envelopment of the dermal papilla forms the bulb and its matrix.
Stage III: The bulb increases in size. Mitotic activity becomes intense. Signs of hair and epithelial-sheath differentiation appear. Melanocyte activity begins.
Stage IV: Keratinization of hair takes place.
Stage V: The hair grows flush with the epidermal surface.
Stage VI: Visible hair emerges.
In this phase — about three weeks — the follicle regresses. Cells become keratinized. Mitotic activity stops. The follicle takes the form of a club.
The quiescent phase lasts about three months. The hair remains anchored in the follicle and continues to rise. At the end, the hair falls, and a new cycle starts. During the hyperproliferative anagen phase, the follicle requires a particular physical, biochemical, and psychological balance to develop normally. Any stressors can thrust anagen follicles back into telogen phase, a condition called alopecia or baldness. There are three types:
- Traumatic alopecia,
- Alopecia due to disease, and
- Androgenetic alopecia.
To restart the hair cycle, a treatment must reactivate the anagen growth phase by acting simultaneously on three factors:
- Hormone balance,
- Vascular system, and
- Cell metabolism.
Tested at 0.25% on normal human fibroblasts, Lupinus albus extract inhibits by 18 percent the activity of 5α-reductase II, an enzyme that enables conversion of testosterone into the 5α-dihydrotestosterone that causes male pattern baldness.
Androgens play a fundamental role in this phenomenon, characterized by dwindling hair diameter, a process called miniaturization. In the course of androgenetic alopecia, follicles experience increased activity from the enzyme 5α-reductase II and higher levels of the hormone 5α-dihydrotestosterone (5α-DHT).
The 5α-DHT appears to be the most important factor in miniaturization. It binds to androgen receptors and forms a hormone/receptor complex that activates the genes responsible for hair shedding.
Tested at 0.5%, Lupinus albus extract increases the synthesis of vascular endothelial growth factor (VEGF) by 30 percent. L albus extract makes the existing vascular system of the hair follicle denser to facilitate better nutrient supply to cells.
Vascularization of a follicle is essential for development and growth, especially in anagen phase. Growth factors, cytokines, and other molecules are involved. One essential growth factor is VEGF, known to stimulate angiogenesis and vascular permeability. VEGF acts directly on dermal ridges and stimulates formation of a robust vascular system in proximity to follicles, fulfilling their nutritional needs. Levels are lower in individuals suffering from androgenetic alopecia, resulting in less-than-adequate vascularization.
During anagen phase, cellular activity is intense. Cells divide continuously to manufacture hair strands. After differentiation, fibers accumulate keratin, hardening and leading to the disintegration of nuclei. A growing hair is prima facie evidence of cellular multiplication. Pressure pushes the hair out through the surface.
Lupinus albus extract provides peptides, zinc, and iron to stimulate the metabolic activity of hair-bulb cells and boost keratinocyte differentiation, as seen in the 44-percent increase in expression of mRNA coding for type 1 transglutaminase (L albus extract at 1%).
Primary ingredient: Lupinus albus extract
Inactive ingredients: deionized water, glycerol (vegetable origin), xanthan gum, isostearyl lactate, phenoxyethanol
Part hair and apply 15 pumps onto the area affected by hair loss or thinning. Rub the solution into the scalp and allow it to dry. Wait at least three hours before washing hair, swimming, or engaging in strenuous exercise. For best results, apply twice daily without skipping.