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Sinere nanominox-fms

$99
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Nanominox-FMS - Finasterid + Minoxidil sulfate


Active ingredients :


minoxidil sulfate 4%

finasteride 0.1%

adenosine

sophora flavescens extract

creatine ethyl ester

cepharanthine

cyanocobalamine (Vitamin B12)

ketoconazole

 

Antioxidants : ascorbic acid (vitamin C), gamma tocopherol (vitamin E)

 

Vehicle :

coated PG-liposomes from high quality phosphatidylcholine

Propylene glycol (PG) 10%

carrageenan

distilled water

 

Consistency :  liquid

 

Suggested use :  Apply 1 to 2 times daily to scalp and gently massage in. The product will be absorbed by the skin very fast and with virtually no visible residue. But to be sure reasonable absorption took place, let the product be absorbed for at least 10 minutes, in case you want to wash your hair after the application. For best results apply consistently.

 

Storage :  Store at room temperature.

 

Product description :

Nanominox©-FMS has some common ingredients with Nanominox©-MS  (please read the text of the product Nanominox©) but it contains minoxidil sulfate instead of plain Minoxidil and it uses another vehicle, PG-liposomes. Minoxidil sulfate is the active metabolite of minoxidil.  Minoxidil is a hair growth promoter that must be metabolized by sulfation to the active compound, minoxidil sulphate, before it can exert its positive effect on the proliferation of the dermal papilla cells of the hair follicle [1].  We incorporate 4% minoxidil sulfate. But that does not mean we arrive at an too high 56% minoxidil concentration equivalent, because not all minoxidil sulfate will stay stable in the solution.

We enacapsulated all ingredients in coated PG-liposomes, which protect the ingredients from degradation to some degree. The coating with carrageenan was already effective in protecting Finasteride from degradation in coated liposomes in an experiment by B. Biruss and C. Valenta [5]. The coating also reduced the diffusion rate of Finasteride out of the liposomes thereby keeping the substance inside the liposomes for a substancially longer time in [5]. We assume the coating will also help to keep our Minoxidil sulfate inside the PG-liposomes. The coating did not only increased the chemical stability of the incorporated substances but also the microbial stability of these substances in liposomes in [5]. In addition, we do not coat normal plain traditional liposomes, we coat a very new vehicle, PG-liposomes. PG-liposomes were superior to all other liposomal vehicles when it comes to the deposition of the difficult to process drug cinchocaine in the skin as was shown by Elsayed et al. in [6]. Quote from [6] :

"PG-liposomes with 10% PG significantly improved
(P<0.01) cinchocaine="" skin="" deposition="" relative="" to="" all="" other="" br="">liposomal formulations, even relative to deformable liposomes
and ethosomes, having reported promising properties as carriers
for skin delivery of drugs. Skin-deposited cinchocaine was
3.0-, 2.1-, 2.6- and 2.0-fold higher from PG-liposomes with
10% PG, relative to traditional liposomes, cholesterol-containing
traditional liposomes, deformable liposomes and ethosomes,
respectively."

PG-liposomes also show very good entrapment efficiency. Quote from [6] :

"Cinchocaine PG-liposomes with 10% PG
showed significantly improved entrapment efficiency over
traditional liposomes and ethosomes."

Our PG-liposomes contain only 10 Propylene glycol (PG). This is a 5 times reduction in PG content compared to a standard Minoxidil product which contains 50% PG and in addition 30% ethanol (alcohol). Our PG-liposomal Minxidil product does contain only 10% PG and no ethanol. Ethanol and PG can cause problems to some users and especially PG is a component, some users develop allergies against.

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